Studien zum fortgeschrittenen Mammakarzinom

ASCENT-03 (EudraCT: 2021-005743-79)

A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients With Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do Not Express PD-L1 or in Patients Previously Treated With Anti-PD(L)1 Agents in the Early Setting Whose Tumors do Express PD-L1

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ASCENT-04 (EudraCT: 2021-005742-14)

A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced, Inoperable, or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1

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ASCENT-07 (EudraCT: 2024-02-28)

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

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SGNTUC-028/HER2CLIMB-05 (EudraCT number 2021-002491-39)

A randomized, double blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for metastatic HER2+ breast cancer (HER2CLIMB-05)

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DESTINIY-Breast 07

A Phase 1b/2 Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to Explore the Safety, Tolerability, and Anti-tumour Activity of Trastuzumab Deruxtecan (T-DXd) in Combination with other Anti-cancer Agents in Patients with HER2-positive Metastatic Breast Cancer

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PEMBROLIZUMAB BEIM MAMMAKARZINOM
Eine klinische Studie mit dem Immuncheckpoint-Inhibitor Pembrolizumab zur Bewertung prädiktiver Biomarker bei Patientinnen mit fortgeschrittenen soliden Tumoren mit hoher Tumormutationslast (TMB).

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PADMA (EudraCT number 2016-004482-89)

Randomisierte, unverblindete Phase-IV-Studie mit Palbociclib plus endokriner Therapie im Vergleich zu einer Chemotherapie-basierten Behandlung bei Patienten mit Hormonrezeptor-positivem und HER2-negativem metastasiertem Mammakarzinom.

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